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Peptidylglycine alpha-amidating monooxygenase inhibitory.

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Peptidylglycine alpha-amidating monooxygenase inhibitory

   07.07.2019  2 Comments
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Peptidyl-glycine alpha-amidating monooxygenase is an enzyme that catalyzes the biosynthesis of many signaling peptides and, in humans, is encoded by the PAM gene. This enzyme is the only known pathway for generating...

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We now report Peptidylglycine alpha-amidating monooxygenase inhibitory PAM readily catalyzes three alternate monooxygenase reactions--sulfoxidation, amine N-dealkylation, and O-dealkylation. Thus, 4-nitrobenzyl thioacetic acid is converted to the analogous sulfoxide, N- 4-nitrobenzyl glycine is converted to 4-nitrobenzylamine and glyoxylate, and [ 4-nitrobenzyl...

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